Whole-Cell but Not Acellular Pertussis Vaccines Induce Convulsive Activity in Mice: Evidence of a Role for Toxin-Induced Interleukin-1β in a New Murine Model for Analysis of Neuronal Side Effects of Vaccination

Immunization with the whole-cell pertussis vaccine (Pw), while effective at preventing whooping cough in infants, has been associated with local, systemic, and neuronal reactions, including fevers and convulsions in children. In contrast, the new acellular pertussis vaccines (Pa) have a considerably...

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Detalhes bibliográficos
Main Authors: Donnelly, Sheila, Loscher, Christine E., Lynch, Marina A., Mills, Kingston H. G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC98454/
https://ncbi.nlm.nih.gov/pubmed/11401957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.7.4217-4223.2001
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