Attenuated Shigella flexneri 2a ΔguaBA Strain CVD 1204 Expressing Enterotoxigenic Escherichia coli (ETEC) CS2 and CS3 Fimbriae as a Live Mucosal Vaccine against Shigella and ETEC Infection

To construct a prototype hybrid vaccine against Shigella and enterotoxigenic Escherichia coli (ETEC), the genes encoding the production of ETEC CS2 and CS3 fimbriae were isolated and expressed in attenuated Shigella flexneri 2a guaBA strain CVD 1204. The CS2 cotA to -D genes, isolated from ETEC stra...

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Main Authors: Altboum, Zeev, Barry, Eileen M., Losonsky, Genevieve, Galen, James E., Levine, Myron M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2001
Teme:
Microbial Immunity and Vaccines
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC98271/
https://ncbi.nlm.nih.gov/pubmed/11292735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.5.3150-3158.2001
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