Improved Immunogenicity and Protective Efficacy of a Tuberculosis DNA Vaccine Encoding Ag85 by Protein Boosting

C57BL/6 mice were vaccinated with plasmid DNA encoding Ag85 from Mycobacterium tuberculosis, with Ag85 protein in adjuvant, or with a combined DNA prime-protein boost regimen. While DNA immunization, as previously described, induced robust Th1-type cytokine responses, protein-in-adjuvant vaccination...

Полное описание

Библиографические подробности

Опубликовано в::	Infect Immun
Главные авторы:	Tanghe, Audrey, D'Souza, Sushila, Rosseels, Valérie, Denis, Olivier, Ottenhoff, Thomas H. M., Dalemans, Wilfried, Wheeler, Carl, Huygen, Kris
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 2001
Предметы:	Microbial Immunity and Vaccines
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC98258/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11292722/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.5.3041-3047.2001
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