Improved Immunogenicity and Protective Efficacy of a Tuberculosis DNA Vaccine Encoding Ag85 by Protein Boosting

C57BL/6 mice were vaccinated with plasmid DNA encoding Ag85 from Mycobacterium tuberculosis, with Ag85 protein in adjuvant, or with a combined DNA prime-protein boost regimen. While DNA immunization, as previously described, induced robust Th1-type cytokine responses, protein-in-adjuvant vaccination...

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Autori principali: Tanghe, Audrey, D'Souza, Sushila, Rosseels, Valérie, Denis, Olivier, Ottenhoff, Thomas H. M., Dalemans, Wilfried, Wheeler, Carl, Huygen, Kris
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Microbial Immunity and Vaccines
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC98258/
https://ncbi.nlm.nih.gov/pubmed/11292722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.5.3041-3047.2001
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