Intranasal Immunization Enhances Clearance of Nontypeable Haemophilus influenzae and Reduces Stimulation of Tumor Necrosis Factor Alpha Production in the Murine Model of Otitis Media

Nontypeable Haemophilus influenzae (NTHi) is a major pathogen causing otitis media (OM). One of the outer membrane proteins of NTHi, P6, is a common antigen to all strains and is considered a candidate for mucosal vaccine. We have previously reported that intranasal immunization with P6 and cholera...

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Main Authors: Sabirov, Albert, Kodama, Satoru, Hirano, Takashi, Suzuki, Masashi, Mogi, Goro
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Microbial Immunity and Vaccines
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC98249/
https://ncbi.nlm.nih.gov/pubmed/11292713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.5.2964-2971.2001
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