Evaluation of De-O-Acetylated Meningococcal C Polysaccharide-Tetanus Toxoid Conjugate Vaccine in Infancy: Reactogenicity, Immunogenicity, Immunologic Priming, and Bactericidal Activity against O-Acetylated and De-O-Acetylated Serogroup C Strains

The polysaccharide capsule of serogroup C Neisseria meningitidis (MenC) has been integral to vaccine development. Licensed MenC vaccines contain the O-acetylated (OAc+) form of polysaccharide. Some MenC strains have de-O-acetylated (OAc−) polysaccharide, which may affect antibody specificity and fun...

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Pubblicato in:	Infect Immun
Autori principali:	Richmond, Peter, Borrow, Ray, Findlow, Jamie, Martin, Sarah, Thornton, Carol, Cartwright, Keith, Miller, Elizabeth
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Microbial Immunity and Vaccines
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC98168/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11254596/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.4.2378-2382.2001
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