Evaluation of De-O-Acetylated Meningococcal C Polysaccharide-Tetanus Toxoid Conjugate Vaccine in Infancy: Reactogenicity, Immunogenicity, Immunologic Priming, and Bactericidal Activity against O-Acetylated and De-O-Acetylated Serogroup C Strains

The polysaccharide capsule of serogroup C Neisseria meningitidis (MenC) has been integral to vaccine development. Licensed MenC vaccines contain the O-acetylated (OAc+) form of polysaccharide. Some MenC strains have de-O-acetylated (OAc−) polysaccharide, which may affect antibody specificity and fun...

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Главные авторы: Richmond, Peter, Borrow, Ray, Findlow, Jamie, Martin, Sarah, Thornton, Carol, Cartwright, Keith, Miller, Elizabeth
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2001
Предметы:
Microbial Immunity and Vaccines
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC98168/
https://ncbi.nlm.nih.gov/pubmed/11254596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.4.2378-2382.2001
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