Preexposure of Murine Macrophages to CpG Oligonucleotide Results in a Biphasic Tumor Necrosis Factor Alpha Response to Subsequent Lipopolysaccharide Challenge

Bacterial DNA and synthetic oligonucleotides containing CpG sequences (CpG-DNA and CpG-ODN) provoke a proinflammatory cytokine response (tumor necrosis factor alpha [TNF-α], interleukin-12 [IL-12], and IL-6) and increased mortality in lipopolysaccharide (LPS)-challenged mice via a TNF-α-mediated mec...

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Detalhes bibliográficos
Main Authors: Crabtree, Traves D., Jin, Long, Raymond, Daniel P., Pelletier, Shawn J., Houlgrave, C. Webster, Gleason, Thomas G., Pruett, Timothy L., Sawyer, Robert G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC98138/
https://ncbi.nlm.nih.gov/pubmed/11254566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.4.2123-2129.2001
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