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Mutagenesis and Functional Reconstitution of Chlamydial Major Outer Membrane Proteins: VS4 Domains Are Not Required for Pore Formation but Modify Channel Function

Chlamidial organisms are obligate intracellular pathogens containing highly antigenic porin-like major outer membrane proteins (MOMPs). MOMP epitopes are of substantial medical interest, and they cluster within four relatively short variable (VS) domains. If MOMPs adopt a β-barrel fold, like bacteri...

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Detalhes bibliográficos
Main Authors: Hughes, E. S., Shaw, K. M., Ashley, R. H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC98071/
https://ncbi.nlm.nih.gov/pubmed/11179342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.3.1671-1678.2001
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