Use of a Whole Genome Approach To Identify Vaccine Molecules Affording Protection against Streptococcus pneumoniae Infection

Microbial targets for protective humoral immunity are typically surface-localized proteins and contain common sequence motifs related to their secretion or surface binding. Exploiting the whole genome sequence of the human bacterial pathogen Streptococcus pneumoniae, we identified 130 open reading f...

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Hauptverfasser: Wizemann, Theresa M., Heinrichs, Jon H., Adamou, John E., Erwin, Alice L., Kunsch, Charles, Choi, Gil H., Barash, Steven C., Rosen, Craig A., Masure, H. Robert, Tuomanen, Elaine, Gayle, Anthony, Brewah, Yambasu A., Walsh, William, Barren, Philip, Lathigra, Raju, Hanson, Mark, Langermann, Solomon, Johnson, Syd, Koenig, Scott
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Microbial Immunity and Vaccines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC98061/
https://ncbi.nlm.nih.gov/pubmed/11179332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.3.1593-1598.2001
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