Clostridium difficile Toxins Disrupt Epithelial Barrier Function by Altering Membrane Microdomain Localization of Tight Junction Proteins

The anaerobic bacterium Clostridium difficile is the etiologic agent of pseudomembranous colitis. C. difficile toxins TcdA and TcdB are UDP-glucosyltransferases that monoglucosylate and thereby inactivate the Rho family of GTPases (W. P. Ciesla, Jr., and D. A. Bobak, J. Biol. Chem. 273:16021–16026,...

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Dades bibliogràfiques
Autors principals: Nusrat, A., von Eichel-Streiber, C., Turner, J. R., Verkade, P., Madara, J. L., Parkos, C. A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Molecular Pathogenesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC98024/
https://ncbi.nlm.nih.gov/pubmed/11179295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.3.1329-1336.2001
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