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Clostridium difficile Toxins Disrupt Epithelial Barrier Function by Altering Membrane Microdomain Localization of Tight Junction Proteins

The anaerobic bacterium Clostridium difficile is the etiologic agent of pseudomembranous colitis. C. difficile toxins TcdA and TcdB are UDP-glucosyltransferases that monoglucosylate and thereby inactivate the Rho family of GTPases (W. P. Ciesla, Jr., and D. A. Bobak, J. Biol. Chem. 273:16021–16026,...

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Published in:Infect Immun
Main Authors: Nusrat, A., von Eichel-Streiber, C., Turner, J. R., Verkade, P., Madara, J. L., Parkos, C. A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2001
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC98024/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11179295/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.3.1329-1336.2001
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