DNA Immunization by Plasmodium falciparum Liver-Stage Antigen 3 Induces Protection against Plasmodium yoelii Sporozoite Challenge

DNA-based immunization of mice by Plasmodium falciparum liver-stage antigen 3 (PfLSA3), a novel highly conserved P. falciparum preerythrocytic antigen, was evaluated. Animals developed a dominant Th1 immune response (high gamma interferon T-cell responses and predominance of immunoglobulin G2a) to e...

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Bibliographic Details
Main Authors: Sauzet, Jean-Pierre, Perlaza, Blanca-Liliana, Brahimi, Karima, Daubersies, Pierre, Druilhe, Pierre
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Fungal and Parasitic Infections
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC98007/
https://ncbi.nlm.nih.gov/pubmed/11160023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.2.1202-1206.2001
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