Characterization of Auxotrophic Mutants of Mycobacterium tuberculosis and Their Potential as Vaccine Candidates

Auxotrophic mutants of Mycobacterium tuberculosis have been proposed as new vaccine candidates. We have analyzed the virulence and vaccine potential of M. tuberculosis strains containing defined mutations in genes involved in methionine (metB), proline (proC), or tryptophan (trpD) amino acid biosynt...

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Detalhes bibliográficos
Main Authors: Smith, Debbie A., Parish, Tanya, Stoker, Neil G., Bancroft, Gregory J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC97996/
https://ncbi.nlm.nih.gov/pubmed/11160012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.2.1142-1150.2001
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