Combinatorial Library Cloning of Human Antibodies to Streptococcus pneumoniae Capsular Polysaccharides: Variable Region Primary Structures and Evidence for Somatic Mutation of Fab Fragments Specific for Capsular Serotypes 6B, 14, and 23F

Antibodies specific for capsular polysaccharides play a central role in immunity to encapsulated Streptococcus pneumoniae, but little is known about their genetics or the variable (V) region polymorphisms that affect their protective function. To begin to address these issues, we used combinatorial...

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Bibliografski detalji

Izdano u:	Infect Immun
Glavni autori:	Lucas, Alexander H., Moulton, Karen D., Tang, Vanessa R., Reason, Donald C.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 2001
Teme:	Microbial Immunity and Vaccines
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97962/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11159978/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.2.853-864.2001
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