Combinatorial Library Cloning of Human Antibodies to Streptococcus pneumoniae Capsular Polysaccharides: Variable Region Primary Structures and Evidence for Somatic Mutation of Fab Fragments Specific for Capsular Serotypes 6B, 14, and 23F

Antibodies specific for capsular polysaccharides play a central role in immunity to encapsulated Streptococcus pneumoniae, but little is known about their genetics or the variable (V) region polymorphisms that affect their protective function. To begin to address these issues, we used combinatorial...

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Bibliografiset tiedot
Päätekijät: Lucas, Alexander H., Moulton, Karen D., Tang, Vanessa R., Reason, Donald C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2001
Aiheet:
Microbial Immunity and Vaccines
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC97962/
https://ncbi.nlm.nih.gov/pubmed/11159978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.2.853-864.2001
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