Combinatorial Library Cloning of Human Antibodies to Streptococcus pneumoniae Capsular Polysaccharides: Variable Region Primary Structures and Evidence for Somatic Mutation of Fab Fragments Specific for Capsular Serotypes 6B, 14, and 23F

Antibodies specific for capsular polysaccharides play a central role in immunity to encapsulated Streptococcus pneumoniae, but little is known about their genetics or the variable (V) region polymorphisms that affect their protective function. To begin to address these issues, we used combinatorial...

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Bibliographic Details
Main Authors: Lucas, Alexander H., Moulton, Karen D., Tang, Vanessa R., Reason, Donald C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC97962/
https://ncbi.nlm.nih.gov/pubmed/11159978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.2.853-864.2001
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