Pneumolysin Is the Main Inducer of Cytotoxicity to Brain Microvascular Endothelial Cells Caused by Streptococcus pneumoniae

In pneumococcal meningitis it is assumed that bacteria cross the blood-brain barrier (BBB), which consists mainly of cerebral endothelial cells. The effect of Streptococcus pneumoniae on the BBB was investigated with an in vitro BBB model using a human brain microvascular endothelial cell line (HBME...

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Main Authors: Zysk, Gregor, Schneider-Wald, Barbara Katharina, Hwang, Jae Hyuk, Bejo, Levente, Kim, Kwang Sik, Mitchell, Timothy J., Hakenbeck, Regine, Heinz, Hans-Peter
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC97961/
https://ncbi.nlm.nih.gov/pubmed/11159977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.2.845-852.2001
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