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Severe Schistosomiasis in the Absence of Interleukin-4 (IL-4) Is IL-12 Independent

An interleukin-4 (IL-4)-dependent Th2 response allows wild-type mice to survive infection with the parasite Schistosoma mansoni. In the absence of IL-4, infected mice mount a Th1-like proinflammatory response, develop severe disease, and succumb. Neither the Th1 response nor morbidity is IL-12 depen...

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Bibliografische gegevens
Gepubliceerd in:Infect Immun
Hoofdauteurs: Patton, Elisabeth A., Brunet, Laura Rosa, La Flamme, Anne C., Pedras-Vasconcelos, João, Kopf, Manfred, Pearce, Edward J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 2001
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Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97925/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11119559/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.1.589-592.2001
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