Severe Schistosomiasis in the Absence of Interleukin-4 (IL-4) Is IL-12 Independent

An interleukin-4 (IL-4)-dependent Th2 response allows wild-type mice to survive infection with the parasite Schistosoma mansoni. In the absence of IL-4, infected mice mount a Th1-like proinflammatory response, develop severe disease, and succumb. Neither the Th1 response nor morbidity is IL-12 depen...

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Autori principali: Patton, Elisabeth A., Brunet, Laura Rosa, La Flamme, Anne C., Pedras-Vasconcelos, João, Kopf, Manfred, Pearce, Edward J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Fungal and Parasitic Infections
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC97925/
https://ncbi.nlm.nih.gov/pubmed/11119559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.1.589-592.2001
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