Activation of Vα14(+) Natural Killer T Cells by α-Galactosylceramide Results in Development of Th1 Response and Local Host Resistance in Mice Infected with Cryptococcus neoformans

We examined the effect of α-galactosylceramide (α-GalCer) on the synthesis of gamma interferon (IFN-γ) and local resistance in mice infected intravenously with Cryptococcus neoformans. The level of IFN-γ in serum increased on day 3, reached a peak level on day 7, and decreased to the basal level on...

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Main Authors: Kawakami, Kazuyoshi, Kinjo, Yuki, Yara, Satomi, Koguchi, Yoshinobu, Uezu, Kaori, Nakayama, Toshinori, Taniguchi, Masaru, Saito, Atsushi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2001
Teme:
Host Response and Inflammation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC97874/
https://ncbi.nlm.nih.gov/pubmed/11119508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.1.213-220.2001
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