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Expression of the Nitric Oxide Synthase 2 Gene Is Not Essential for Early Control of Mycobacterium tuberculosis in the Murine Lung

The interleukin-12 and gamma interferon (IFN-γ) pathway of macrophage activation plays a pivotal role in controlling tuberculosis. In the murine model, the generation of supplementary nitric oxide by the induction of the nitric oxide synthase 2 (NOS2) gene product is considered the principal antimic...

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Main Authors: Cooper, Andrea M., Pearl, John E., Brooks, Jason V., Ehlers, Stefan, Orme, Ian M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2000
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC97793/
https://ncbi.nlm.nih.gov/pubmed/11083808
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