Immunomodulatory Role of Endogenous Interleukin-18 in Gamma Interferon-Mediated Resolution of Replicative Legionella pneumophila Lung Infection

The in vivo role of endogenous interleukin-18 (IL-18) in modulating gamma interferon (IFN-γ)-mediated resolution of replicative Legionella pneumophila lung infection was assessed using a murine model of Legionnaires' disease. Intratracheal inoculation of A/J mice with virulent bacteria (10(6) L. pne...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Brieland, Joan K., Jackson, Craig, Hurst, Steve, Loebenberg, David, Muchamuel, Tony, Debets, Reno, Kastelein, Rob, Churakova, Tatyana, Abrams, John, Hare, Roberta, O'Garra, Anne
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Host Response and Inflammation
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97751/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11083766/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.12.6567-6573.2000
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