Immunomodulatory Role of Endogenous Interleukin-18 in Gamma Interferon-Mediated Resolution of Replicative Legionella pneumophila Lung Infection

The in vivo role of endogenous interleukin-18 (IL-18) in modulating gamma interferon (IFN-γ)-mediated resolution of replicative Legionella pneumophila lung infection was assessed using a murine model of Legionnaires' disease. Intratracheal inoculation of A/J mice with virulent bacteria (10(6) L...

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Detalhes bibliográficos
Main Authors: Brieland, Joan K., Jackson, Craig, Hurst, Steve, Loebenberg, David, Muchamuel, Tony, Debets, Reno, Kastelein, Rob, Churakova, Tatyana, Abrams, John, Hare, Roberta, O'Garra, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC97751/
https://ncbi.nlm.nih.gov/pubmed/11083766
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