Key Role for DsbA in Cell-to-Cell Spread of Shigella flexneri, Permitting Secretion of Ipa Proteins into Interepithelial Protrusions

DsbA, a disulfide bond catalyst, is necessary for realization of the pathogenic potential of Shigella flexneri. Sh42, a mutant strain differing from wild-type M90TS solely because it expresses nonfunctional DsbA33G (substitution for 33C at the active site), secreted less IpaB and IpaC than M90TS in...

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Pubblicato in:	Infect Immun
Autori principali:	Yu, Jun, Edwards-Jones, Bryn, Neyrolles, Olivier, Kroll, J. Simon
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Molecular and Cellular Pathogenesis
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97732/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11035758/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.11.6449-6456.2000
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