In Vivo Administration of Mycobacterial Cord Factor (Trehalose 6,6′-Dimycolate) Can Induce Lung and Liver Granulomas and Thymic Atrophy in Rabbits

Trehalose 6,6′-dimycolate (TDM) is a cell surface molecule of Mycobacterium tuberculosis. TDM induced a loss of body weight and prominent granulomas in the liver and lungs by the intravenous injection of TDM into rabbits. TDM also induced atrophy of the thymus and spleen due to apoptosis. By contras...

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Pubblicato in:	Infect Immun
Autori principali:	Hamasaki, Naoko, Isowa, Ko-Ichi, Kamada, Kohachi, Terano, Yoshitake, Matsumoto, Takayuki, Arakawa, Tetsuo, Kobayashi, Kazuo, Yano, Ikuya
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Molecular and Cellular Pathogenesis
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97662/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10816531/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.6.3704-3709.2000
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