In Vivo Administration of Mycobacterial Cord Factor (Trehalose 6,6′-Dimycolate) Can Induce Lung and Liver Granulomas and Thymic Atrophy in Rabbits

Trehalose 6,6′-dimycolate (TDM) is a cell surface molecule of Mycobacterium tuberculosis. TDM induced a loss of body weight and prominent granulomas in the liver and lungs by the intravenous injection of TDM into rabbits. TDM also induced atrophy of the thymus and spleen due to apoptosis. By contras...

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Detalhes bibliográficos
Main Authors: Hamasaki, Naoko, Isowa, Ko-Ichi, Kamada, Kohachi, Terano, Yoshitake, Matsumoto, Takayuki, Arakawa, Tetsuo, Kobayashi, Kazuo, Yano, Ikuya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Molecular and Cellular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC97662/
https://ncbi.nlm.nih.gov/pubmed/10816531
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