Structure-dependent reactivity of oxyfunctionalized acetophenones in the photooxidation of DNA: base oxidation and strand breaks through photolytic radical formation (spin trapping, EPR spectroscopy, transient kinetics) versus photosensitization (electron transfer, hydrogen-atom abstraction)

The photooxidative damage of DNA, specifically guanine oxidation and strand-break formation, by sidechain-oxyfunctionalized acetophenones (hydroxy, methoxy, tert-butoxy and acetoxy derivatives), has been examined. The involvement of triplet-excited ketones and their reactivity towards DNA has been d...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Adam, Waldemar, Arnold, Markus A., Nau, Werner M., Pischel, Uwe, Saha-Möller, Chantu R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97623/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11812825/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.24.4955
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