Structure-dependent reactivity of oxyfunctionalized acetophenones in the photooxidation of DNA: base oxidation and strand breaks through photolytic radical formation (spin trapping, EPR spectroscopy, transient kinetics) versus photosensitization (electron transfer, hydrogen-atom abstraction)

The photooxidative damage of DNA, specifically guanine oxidation and strand-break formation, by sidechain-oxyfunctionalized acetophenones (hydroxy, methoxy, tert-butoxy and acetoxy derivatives), has been examined. The involvement of triplet-excited ketones and their reactivity towards DNA has been d...

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Hlavní autoři: Adam, Waldemar, Arnold, Markus A., Nau, Werner M., Pischel, Uwe, Saha-Möller, Chantu R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2001
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC97623/
https://ncbi.nlm.nih.gov/pubmed/11812825
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