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Effective inhibition of herpes simplex virus 1 gene expression and growth by engineered RNase P ribozyme

Using an in vitro selection procedure, we have previously isolated ribonuclease P (RNase P) ribozyme variants that efficiently cleave an mRNA sequence in vitro. In this study, an M1GS RNA variant was used to target the mRNA encoding human herpes simplex virus 1 (HSV-1) major transcription activator...

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Autori principali: Trang, Phong, Lee, Jarone, Kilani, Ahmed F., Kim, Joe, Liu, Fenyong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC97563/
https://ncbi.nlm.nih.gov/pubmed/11812839
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