Immunization of Mice with Combinations of Pneumococcal Virulence Proteins Elicits Enhanced Protection against Challenge with Streptococcus pneumoniae

The vaccine potential of a combination of three pneumococcal virulence proteins was evaluated in an active-immunization–intraperitoneal-challenge model in BALB/c mice, using very high challenge doses of Streptococcus pneumoniae. The proteins evaluated were a genetic toxoid derivative of pneumolysin...

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Publicado en:	Infect Immun
Autores principales:	Ogunniyi, A. David, Folland, Rebekah L., Briles, David E., Hollingshead, Susan K., Paton, James C.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 2000
Materias:	Microbial Immunity and Vaccines
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97524/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10769009/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.5.3028-3033.2000
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