Induction of Necrosis in Human Neutrophils by Shigella flexneri Requires Type III Secretion, IpaB and IpaC Invasins, and Actin Polymerization

Infection by Shigella flexneri is characterized by infiltration of neutrophils in the intestinal mucosa and by a strong inflammatory reaction. Although neutrophils are constitutively programmed to die by apoptosis, we show that isolated human neutrophils undergo necrosis 2 h after infection with vir...

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Publié dans:	Infect Immun
Auteurs principaux:	François, Mathias, Le Cabec, Véronique, Dupont, Marie-Ange, Sansonetti, Philippe J., Maridonneau-Parini, Isabelle
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2000
Sujets:	Molecular and Cellular Pathogenesis
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97281/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10678940/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.3.1289-1296.2000
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