Induction of Necrosis in Human Neutrophils by Shigella flexneri Requires Type III Secretion, IpaB and IpaC Invasins, and Actin Polymerization

Infection by Shigella flexneri is characterized by infiltration of neutrophils in the intestinal mucosa and by a strong inflammatory reaction. Although neutrophils are constitutively programmed to die by apoptosis, we show that isolated human neutrophils undergo necrosis 2 h after infection with vir...

Full description

Bibliographic Details

Published in:	Infect Immun
Main Authors:	François, Mathias, Le Cabec, Véronique, Dupont, Marie-Ange, Sansonetti, Philippe J., Maridonneau-Parini, Isabelle
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 2000
Subjects:	Molecular and Cellular Pathogenesis
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97281/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10678940/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.3.1289-1296.2000
Tags:	Add Tag No Tags, Be the first to tag this record!