Shigella flexneri 2a Strain CVD 1207, with Specific Deletions in virG, sen, set, and guaBA, Is Highly Attenuated in Humans

A phase 1 clinical trial was conducted among 35 healthy adult volunteers to evaluate the safety, immunogenicity, and shedding of different doses of CVD 1207, a live attenuated Shigella flexneri 2a vaccine candidate with specific deletion mutations in virG, sen, set, and guaBA. CVD 1207 retains the a...

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Hauptverfasser: Kotloff, Karen L., Noriega, Fernando R., Samandari, Taraz, Sztein, Marcelo B., Losonsky, Genevieve A., Nataro, James P., Picking, William D., Barry, Eileen M., Levine, Myron M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2000
Schlagworte:
Microbial Immunity and Vaccines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC97245/
https://ncbi.nlm.nih.gov/pubmed/10678904
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