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Comparison of the Roles of Calcineurin in Physiology and Virulence in Serotype D and Serotype A Strains of Cryptococcus neoformans

The calcineurin gene was cloned and disrupted in serotype D strains of Cryptococcus neoformans. Serotype A and serotype D calcineurin mutants were inviable at 37°C and avirulent in mice, whereas only serotype A mutants were cation stress sensitive. Thus, calcineurin plays conserved and divergent rol...

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Bibliografiska uppgifter
Huvudupphovsmän: Cruz, M. Cristina, Sia, Rey A. L., Olson, Michael, Cox, Gary M., Heitman, Joseph
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2000
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC97236/
https://ncbi.nlm.nih.gov/pubmed/10639477
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