Igh-6(−/−) (B-Cell-Deficient) Mice Fail To Mount Solid Acquired Resistance to Oral Challenge with Virulent Salmonella enterica Serovar Typhimurium and Show Impaired Th1 T-Cell Responses to Salmonella Antigens

In the present study we evaluated the role of B cells in acquired immunity to Salmonella infection by using gene-targeted B-cell-deficient innately susceptible mice on a C57BL/6 background (Igh-6(−/−)). Igh-6(−/−) mice immunized with a live, attenuated aroA Salmonella enterica serovar Typhimurium va...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Mastroeni, Pietro, Simmons, C., Fowler, R., Hormaeche, C. E., Dougan, G.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Microbial Immunity and Vaccines
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97100/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10603367/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.1.46-53.2000
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