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Igh-6(−/−) (B-Cell-Deficient) Mice Fail To Mount Solid Acquired Resistance to Oral Challenge with Virulent Salmonella enterica Serovar Typhimurium and Show Impaired Th1 T-Cell Responses to Salmonella Antigens

In the present study we evaluated the role of B cells in acquired immunity to Salmonella infection by using gene-targeted B-cell-deficient innately susceptible mice on a C57BL/6 background (Igh-6(−/−)). Igh-6(−/−) mice immunized with a live, attenuated aroA Salmonella enterica serovar Typhimurium va...

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Detalhes bibliográficos
Main Authors: Mastroeni, Pietro, Simmons, C., Fowler, R., Hormaeche, C. E., Dougan, G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC97100/
https://ncbi.nlm.nih.gov/pubmed/10603367
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