Cognate Stimulatory B-Cell–T-Cell Interactions Are Critical for T-Cell Help Recruited by Glycoconjugate Vaccines

Covalent linkage of a bacterial polysaccharide to an immunogenic protein greatly enhances the carbohydrate's immunogenicity and induces polysaccharide-specific B-cell memory in vivo. These findings have spurred the development of glycoconjugate vaccines for serious bacterial infections. The spe...

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Detalhes bibliográficos
Main Authors: Guttormsen, Hilde-Kari, Sharpe, Arlene H., Chandraker, Anil K., Brigtsen, Anne Karin, Sayegh, Mohammed H., Kasper, Dennis L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1999
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC97045/
https://ncbi.nlm.nih.gov/pubmed/10569753
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