The Autolysin-Encoding Gene (lytA) of Streptococcus pneumoniae Displays Restricted Allelic Variation despite Localized Recombination Events with Genes of Pneumococcal Bacteriophage Encoding Cell Wall Lytic Enzymes

The lytA-encoded autolysin (N-acetylmuramoyl-l-alanine amidase) of Streptococcus pneumoniae is believed to play an important role in the pathogenesis of pneumococcal infection and has been identified as a putative vaccine target. Allelic diversity of lytA in an extensive collection of clinical isola...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Whatmore, Adrian M., Dowson, Christopher G.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Molecular Genomics
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96777/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10456899/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.9.4551-4556.1999
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