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The Autolysin-Encoding Gene (lytA) of Streptococcus pneumoniae Displays Restricted Allelic Variation despite Localized Recombination Events with Genes of Pneumococcal Bacteriophage Encoding Cell Wall Lytic Enzymes

The lytA-encoded autolysin (N-acetylmuramoyl-l-alanine amidase) of Streptococcus pneumoniae is believed to play an important role in the pathogenesis of pneumococcal infection and has been identified as a putative vaccine target. Allelic diversity of lytA in an extensive collection of clinical isola...

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Bibliografiske detaljer
Main Authors: Whatmore, Adrian M., Dowson, Christopher G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC96777/
https://ncbi.nlm.nih.gov/pubmed/10456899
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