An Arcanobacterium (Actinomyces) pyogenes Mutant Deficient in Production of the Pore-Forming Cytolysin Pyolysin Has Reduced Virulence

Pyolysin (PLO), the hemolytic exotoxin expressed by Arcanobacterium (Actinomyces) pyogenes, is a member of the thiol-activated cytolysin family of bacterial toxins. Insertional inactivation of the plo gene results in loss of expression of PLO with a concomitant loss in hemolytic activity. The plo mu...

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Publié dans:	Infect Immun
Auteurs principaux:	Jost, B. H., Songer, J. G., Billington, S. J.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1999
Sujets:	Molecular and Cellular Pathogenesis
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96520/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10085010/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.4.1723-1728.1999
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