Immunization with Genetic Toxoids of the Arcanobacterium pyogenes Cholesterol-Dependent Cytolysin, Pyolysin, Protects Mice against Infection

Pyolysin (PLO), a cholesterol-dependent cytolysin expressed by Arcanobacterium pyogenes, is an important host-protective antigen. However, this molecule is toxic and requires inactivation prior to its use as a vaccine. Three genetically toxoided, nonhemolytic PLO molecules, HIS-PLO.F(497), HIS-PLO.Δ...

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Detalles Bibliográficos

Publicado en:	Infect Immun
Principais autores:	Jost, B. Helen, Trinh, Hien T., Songer, J. Glenn, Billington, Stephen J.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 2003
Assuntos:	Molecular Pathogenesis
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153263/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12704180/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.5.2966-2969.2003
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