Immunization with Genetic Toxoids of the Arcanobacterium pyogenes Cholesterol-Dependent Cytolysin, Pyolysin, Protects Mice against Infection

Pyolysin (PLO), a cholesterol-dependent cytolysin expressed by Arcanobacterium pyogenes, is an important host-protective antigen. However, this molecule is toxic and requires inactivation prior to its use as a vaccine. Three genetically toxoided, nonhemolytic PLO molecules, HIS-PLO.F(497), HIS-PLO.Δ...

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Detaylı Bibliyografya
Asıl Yazarlar: Jost, B. Helen, Trinh, Hien T., Songer, J. Glenn, Billington, Stephen J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2003
Konular:
Molecular Pathogenesis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC153263/
https://ncbi.nlm.nih.gov/pubmed/12704180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.5.2966-2969.2003
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