Comparative Virulence of Streptococcus pneumoniae Strains with Insertion-Duplication, Point, and Deletion Mutations in the Pneumolysin Gene

Pneumolysin is a 471-amino-acid toxin produced by Streptococcus pneumoniae which has both cytolytic and complement activation properties. We have constructed a derivative of the type 2 S. pneumoniae strain D39 in which the portion of the pneumolysin gene encoding amino acids 55 to 437 has been delet...

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Pubblicato in:	Infect Immun
Autori principali:	Berry, Anne M., Ogunniyi, A. David, Miller, David C., Paton, James C.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1999
Soggetti:	Molecular and Cellular Pathogenesis
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96416/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9916120/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.2.981-985.1999
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