Therapy with a Combination of Low Doses of Interleukin 12 and Chloroquine Completely Cures Blood-Stage Malaria, Prevents Severe Anemia, and Induces Immunity to Reinfection

The immunoregulatory cytokine interleukin 12 (IL-12) induces host resistance against experimental malaria. In this study, we tested the feasibility of using IL-12 in combination with chloroquine (CQ) to rescue susceptible A/J mice from lethal blood-stage Plasmodium chabaudi AS infection. Combined tr...

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Hlavní autoři: Mohan, Karkada, Sam, Hakeem, Stevenson, Mary M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 1999
Témata:
Fungal and Parasitic Infections
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC96349/
https://ncbi.nlm.nih.gov/pubmed/9916053
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