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Novel Posttranslational Activation of the LYS2-Encoded α-Aminoadipate Reductase for Biosynthesis of Lysine and Site-Directed Mutational Analysis of Conserved Amino Acid Residues in the Activation Domain of Candida albicans

The α-aminoadipate pathway for lysine biosynthesis is present only in fungi. The α-aminoadipate reductase (AAR) of this pathway catalyzes the conversion of α-aminoadipic acid to α-aminoadipic-δ-semialdehyde by a complex mechanism involving two gene products, Lys2p and Lys5p. The LYS2 and LYS5 genes...

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Udgivet i:J Bacteriol
Principais autores: Guo, Shujuan, Evans, Sarah A., Wilkes, Mindy B., Bhattacharjee, J. K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Eukaryotic Cells
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC95560/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11717270/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.183.24.7120-7125.2001
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