Novel Posttranslational Activation of the LYS2-Encoded α-Aminoadipate Reductase for Biosynthesis of Lysine and Site-Directed Mutational Analysis of Conserved Amino Acid Residues in the Activation Domain of Candida albicans

The α-aminoadipate pathway for lysine biosynthesis is present only in fungi. The α-aminoadipate reductase (AAR) of this pathway catalyzes the conversion of α-aminoadipic acid to α-aminoadipic-δ-semialdehyde by a complex mechanism involving two gene products, Lys2p and Lys5p. The LYS2 and LYS5 genes...

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Autors principals: Guo, Shujuan, Evans, Sarah A., Wilkes, Mindy B., Bhattacharjee, J. K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Eukaryotic Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC95560/
https://ncbi.nlm.nih.gov/pubmed/11717270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.183.24.7120-7125.2001
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