Biological and Biochemical Characterization of Variant A Subunits of Cholera Toxin Constructed by Site-Directed Mutagenesis

Cholera toxin (CT) is the prototype for the Vibrio cholerae-Escherichia coli family of heat-labile enterotoxins having an AB5 structure. By substituting amino acids in the enzymatic A subunit that are highly conserved in all members of this family, we constructed 23 variants of CT that exhibited dec...

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Pubblicato in:	J Bacteriol
Autori principali:	Jobling, Michael G., Holmes, Randall K.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Genetics and Molecular Biology
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC95286/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11395467/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.183.13.4024-4032.2001
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