Construction and Characterization of Mutations at Codon 751 of the Escherichia coli gyrB Gene That Confer Resistance to the Antimicrobial Peptide Microcin B17 and Alter the Activity of DNA Gyrase

Microcin B17 is a peptide antibiotic that inhibits DNA replication in Escherichia coli by targeting DNA gyrase. Previously, two independently isolated microcin B17-resistant mutants were shown to harbor the same gyrB point mutation that results in the replacement of tryptophan 751 by arginine in the...

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Pubblicato in:	J Bacteriol
Autori principali:	del Castillo, Francisco J., del Castillo, Ignacio, Moreno, Felipe
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Genetics and Molecular Biology
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC95114/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11222617/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.183.6.2137-2140.2001
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