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Lowering S-Adenosylmethionine Levels in Escherichia coli Modulates C-to-T Transition Mutations

Deoxycytosine methylase (Dcm) enzyme activity causes mutagenesis in vitro either directly by enzyme-induced deamination of cytosine to uracil in the absence of the methyl donor, S-adenosylmethionine (SAM), or indirectly through spontaneous deamination of [5-methyl]cytosine to thymine. Using a Lac re...

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Detalles Bibliográficos
Main Authors: Macintyre, Georgina, Atwood, C. Victoria, Cupples, Claire G.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC94959/
https://ncbi.nlm.nih.gov/pubmed/11208790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.183.3.921-927.2001
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