Lowering S-Adenosylmethionine Levels in Escherichia coli Modulates C-to-T Transition Mutations

Deoxycytosine methylase (Dcm) enzyme activity causes mutagenesis in vitro either directly by enzyme-induced deamination of cytosine to uracil in the absence of the methyl donor, S-adenosylmethionine (SAM), or indirectly through spontaneous deamination of [5-methyl]cytosine to thymine. Using a Lac re...

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Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Macintyre, Georgina, Atwood, C. Victoria, Cupples, Claire G.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Genetics and Molecular Biology
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC94959/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11208790/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.183.3.921-927.2001
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