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Lowering S-Adenosylmethionine Levels in Escherichia coli Modulates C-to-T Transition Mutations
Deoxycytosine methylase (Dcm) enzyme activity causes mutagenesis in vitro either directly by enzyme-induced deamination of cytosine to uracil in the absence of the methyl donor, S-adenosylmethionine (SAM), or indirectly through spontaneous deamination of [5-methyl]cytosine to thymine. Using a Lac re...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC94959/ https://ncbi.nlm.nih.gov/pubmed/11208790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.183.3.921-927.2001 |
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