Action of Deferoxamine against Pneumocystis carinii

We found earlier that deferoxamine (DFO), a drug used for treatment of iron overload, is active against a rat model of Pneumocystis carinii pneumonia (PCP). We had assumed a mode of action by deprivation of nutritional iron; however, data here show that DFO penetrates P. carinii, causing irreversibl...

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Autori principali: Clarkson, Allen B., Turkel-Parrella, David, Williams, Jonathan H., Chen, Lung Chi, Gordon, Terry, Merali, Salim
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC90869/
https://ncbi.nlm.nih.gov/pubmed/11709340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.12.3560-3565.2001
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