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Staphylococcus aureus Mutants Selected by BMS-284756

BMS-284756, a novel des-fluoro(6)-quinolone, was used to select for in vitro mutants of Staphylococcus aureus ISP794. Step mutants were obtained, and the quinolone resistance-determining regions of four target genes, gyrA, gyrB, grlA, and grlB, were sequenced. The data suggest that DNA gyrase is the...

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Autori principali: Discotto, L. F., Lawrence, L. E., Denbleyker, K. L., Barrett, J. F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC90825/
https://ncbi.nlm.nih.gov/pubmed/11600399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.11.3273-3275.2001
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